Meiosis in Animal & Plant cells (AQA A Level Biology): Revision Note
Exam code: 7402
Meiosis in animal & plant cells
Meiosis is a form of nuclear division that results in the production of haploid cells from diploid cells
It produces gametes in plants and animals that are used in sexual reproduction
It has many similarities to mitosis however, it has two divisions: meiosis I and meiosis II
Within each division, there are the following stages: prophase, metaphase, anaphase and telophase
Meiosis I
Meiosis I is the first division in meiosis
It separates homologous chromosomes and reduces the chromosome number by half, producing two haploid cells
Prophase I
DNA replication has already occurred
DNA condenses and becomes visible as chromosomes
The chromosomes are arranged side by side in homologous pairs
Crossing over of non-sister chromatids may occur
The spindle is formed by centrioles
The nuclear envelope breaks down, and the nucleolus disintegrates
Metaphase I
Homologous pairs of chromosomes line up randomly along the equator of the spindle
Independent segregation occurs in metaphase I
Anaphase I
The homologous pairs of chromosomes are separated as microtubules pull whole chromosomes to opposite ends of the spindle
The centromeres do not divide
Telophase I
The chromosomes arrive at opposite poles
Spindle fibres start to break down
Nuclear envelopes form around the two groups of chromosomes, and nucleoli reform
The cell then divides by cytokinesis, forming two haploid daughter cells — each with half the original chromosome number (but still with duplicated chromosomes)
These cells are haploid as they contain half the number of centromeres


Meiosis II
There is no interphase between meiosis I and meiosis II, so the DNA is not replicated
The second division of meiosis is almost identical to the stages of mitosis
Prophase II
The nuclear envelope breaks down and chromosomes condense
A spindle forms at a right angle to the old one
Metaphase II
Chromosomes (still made of two sister chromatids) line up in a single file along the equator of the spindle
Anaphase II
Centromeres divide, and individual chromatids are pulled to opposite poles
Each chromatid is now an individual chromosome
This creates four groups of chromosomes that have half the number of chromosomes compared to the original parent cell
Telophase II
Nuclear membranes form around each group of chromosomes
Cytokinesis occurs
Cytoplasm divides as new cell surface membranes are formed, creating four haploid cells


Examiner Tips and Tricks
Understanding the difference between chromosomes and chromatids can be tricky. Chromosomes are counted by centromeres—so even after DNA replication in interphase, the number of chromosomes stays at 46 because there are still 46 centromeres. However, each chromosome now consists of two sister chromatids, making a total of 92 chromatids.
You need to be able to complete diagrams showing the chromosome content of cells after the first and second meiotic divisions, when given the chromosome content of the parent cell.
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