Treatments for CVD - Benefits & Risks (Edexcel International AS Biology): Revision Note

Treatments for CVD: Benefits & Risks

• While reducing the risk factors and lowering the risk of developing cardiovascular disease (CVD) is the best option, CVD is still very common and treatment options are needed

• There are a number of different treatment options for cardiovascular disease, many of which involve taking medication

• Types of medication for the treatment of CVD include

  • Antihypertensives

  • Statins

  • Anticoagulants

  • Platelet inhibitors

Antihypertensives

• These drugs work by lowering blood pressure

  • High blood pressure is also known as hypertension

• Lowering blood pressure reduces the risk of arterial endothelial damage and therefore reduces the risk of atheromas and thrombosis

• Beta blockers, vasodilators and diuretics act as antihypertensives

  • Beta blockers prevent increases in heart rate

  • Vasodilators increase the diameter of the blood vessels

    • ACE inhibitors are a type of drug that block the production of angiotensin, a hormone that causes constriction of the blood vessels

    • This keeps the arteries dilated, which lowers the blood pressure

  • Diuretics reduce blood volume by decreasing the amount of sodium reabsorbed into the blood by the kidneys, therefore decreasing the volume of water reabsorbed into the blood

Statins

• These drugs work by lowering blood cholesterol 

  • They block an enzyme in the liver which is needed to make cholesterol

• This lowers the LDL concentration in the blood therefore reducing the risk of atheroma formation

  • LDLs are sometimes known as 'bad' cholesterol; at high levels they increase the risk of atheromas forming

• Statins also reduce inflammation in the arterial lining, which lowers the risk of atherosclerosis

Anticoagulants

• These drugs reduce blood clotting

  • Blood clotting can be referred to as blood coagulation

  • Warfarin is an anticoagulant that decreases the level of prothrombin in the bloodstream

• Reduced formation of blood clots decreases the likelihood of thrombosis and therefore reduces the risk of blood vessels being blocked by blood clots

Platelet inhibitors

• These are also substances which reduce blood clotting

  • Platelet inhibitors are a type of anticoagulant

  • Aspirin and clopidogrel are the most commonly used examples of these drugs

• They prevent the clumping together of platelets, so preventing the formation of blood clots

Benefits and Risks of Cardiovascular Disease Drugs Table