Manufacture of Aspirin (AQA A Level Chemistry): Revision Note

Exam code: 7405

Stewart Hird

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Manufacture of Aspirin

Manufacture of Aspirin

  • Acylation reactions have many uses, such as in the pharmaceutical and textile industries for making drugs, e.g. aspirin, and textiles, e.g. cellulose acetate

  • In the industrial manufacture of aspirin, salicylic acid and ethanoic anhydride are reacted together in an acylation reaction to form aspirin and ethanoic acid

Equation for synthesising aspirin, downloadable AS & A Level Chemistry revision notes

     Salicylic acid            Ethanoic anhydride                    Aspirin                               Ethanoic acid

Equation showing the manufacture of aspirin

  • The reaction of acyl chlorides with water or alcohols produces carboxylic acid and esters respectively

    • However it is normally a fast, exothermic process with a rapid production of highly corrosive hydrogen chloride gas

  • In general, acid anhydrides are preferred over acyl chlorides in the production of aspirin because they are also cheaper to produce, less reactive and the reactions can be more easily controlled

  • For acid anhydrides, the by-product is the less corrosive carboxylic acid compared to hydrogen chloride for acyl chlorides

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Stewart Hird

Author: Stewart Hird

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Stewart has been an enthusiastic GCSE, IGCSE, A Level and IB teacher for more than 30 years in the UK as well as overseas, and has also been an examiner for IB and A Level. As a long-standing Head of Science, Stewart brings a wealth of experience to creating Topic Questions and revision materials for Save My Exams. Stewart specialises in Chemistry, but has also taught Physics and Environmental Systems and Societies.

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