Ventilation & Gas Exchange (AQA AS Biology): Revision Note
Exam code: 7401
Ventilation & gas exchange
Gas exchange in the lungs occurs when:
oxygen diffuses down its concentration gradient from the air into the blood
carbon dioxide diffuses down its concentration gradient from the blood into the air
The concentration gradients required for effective gas exchange are maintained by:
ventilation in the lungs
the continuous flow of blood in the capillaries
Ventilation
Ventilation is the process of moving air in and out of the lungs; this involves:
breathing in, or inhalation
breathing out, or exhalation
Examiner Tips and Tricks
Be careful not to confuse ventilation and respiration: ventilation is breathing in and out, while respiration is a chemical reaction that releases chemical energy from biological molecules
Breathing in
The mechanism by which air is drawn into the lungs is as follows:
The diaphragm contracts and flattens and the external intercostal muscles contract
The ribcage moves upwards and outwards
Chest volume increases, resulting in a pressure decrease
Air moves into the lungs down a pressure gradient
The process of breathing out is active; it requires energy for muscle contraction

Breathing out
The mechanism by which air is forced out of the lungs is as follows:
The diaphragm relaxes and curves upwards and the external intercostal muscles relax
The ribcage moves downwards and inwards
Chest volume decreases, resulting in a pressure increase
Air moves out of the lungs down a pressure gradient
When at rest breathing out is a passive process that occurs due to the elastic recoil of the lung tissue

During forced exhalation the process can become active:
Internal intercostal muscles contract to pull the ribs down and the abdominal muscles contract to push organs upwards against the diaphragm
These actions decrease the chest volume further, increasing the pressure and forcing more air out of the lungs
Examiner Tips and Tricks
The intercostal muscles work against each other in an antagonistic manner; as one contracts, the other relaxes.
Calculating pulmonary ventilation rate
The volume of air breathed by an individual over a minute is known as the pulmonary ventilation rate (PVR); it is determined by:
breathing rate: the number of breaths per minute
tidal volume: volume of air breathed in per normal breath
PVR can be calculated as follows:
PVR = tidal volume x breathing rate
Worked Example
An individual's pulmonary ventilation rate at rest was found to be 7.4 dm3 min-1. They took 12 breaths in one minute.
Calculate the individual's tidal volume.
Step one: rearrange the equation
PVR = tidal volume x breathing rate
Rearrange to:
tidal volume = PVR ÷ breathing rate
Step two: insert relevant values into equation
tidal volume = 7.4 ÷ 12
= 0.6166
tidal volume = 0.62 dm3
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