Meiosis (AQA AS Biology): Revision Note
Exam code: 7401
Meiosis
Meiosis produces daughter cells that are genetically different from each other and to the parent cell
This is due to the processes of independent segregation and crossing over
Independent segregation
The independent segregation of homologous chromosomes leads to genetically different daughter cells
This happens during meiosis:
Meiosis is the process that forms gametes (sperm or egg), and it has two divisions: meiosis I and meiosis II
During meiosis I, homologous chromosomes line up in the centre of the cell
The chromosomes are then separated and pulled into different cells — this is called segregation of homologous chromosomes
Each pair of homologous chromosomes lines up randomly
That means the way one pair segregates does not affect how another pair segregates
This is what makes it independent — each chromosome pair has its a different path by chance

Examiner Tips and Tricks
The AQA specification refers to independent segregation, but you may also see the term independent assortment. Use the phrase "independent segregation of homologous chromosomes" to stick to specification language. 'Independent assortment' will often be accepted in explanations in your answers, but 'independent segregation' is more precise for AQA.
Crossing over
Crossing over is the process where homologous chromosomes exchange genetic material during meiosis I
This process results in further genetic variation among daughter cells
Homologous chromosomes pair up and form bivalents
The chromatid then breaks and rejoins to the chromatid of its homologous chromosome, so that its alleles are exchanged
Crossing over leads to new combinations of alleles on each chromatid; this is called recombination

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