Exam code: J250
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Define hormone.
A chemical messenger produced by a gland and carried in the blood, which alters the activity of a target organ.

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Define endocrine system.
The system of glands that produce and release hormones into the bloodstream.
How are hormones transported around the body?
Dissolved in the blood plasma.
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Define hormone.
A chemical messenger produced by a gland and carried in the blood, which alters the activity of a target organ.
Define endocrine system.
The system of glands that produce and release hormones into the bloodstream.
How are hormones transported around the body?
Dissolved in the blood plasma.
Why do endocrine glands need a good blood supply?
So the hormones they make reach the bloodstream quickly and can travel to their target organs.
Why does a hormone affect only certain cells?
Only target cells carry receptors with a shape complementary to the hormone, so only they can bind it and respond.
Where are hormone receptors found on a target cell?
On the cell membrane, or inside the cell.
Compare the speed of nervous and hormonal responses.
Nervous responses are very fast but short-lived.
Hormonal responses are slower to start but last much longer.
Give one advantage of hormonal control over nervous control.
Its effects last much longer, which suits processes that need sustained control rather than an instant response.
Hormones are produced by ________ and carried in the blood to their target organs.
Hormones are produced by glands and carried in the blood to their target organs.
A hormone can only affect a cell that has a complementary ________.
A hormone can only affect a cell that has a complementary receptor.
True or False?
Hormones travel to their target organ along nerves.
False.
They are carried in the blood. Only nervous impulses travel along nerves.
Which gland produces thyroxine? (Higher Tier Only)
The thyroid gland, in the neck.
What is the role of thyroxine? (Higher Tier Only)
It controls the body's metabolic rate — the rate at which the chemical reactions in cells take place.
How is thyroxine an example of negative feedback? (Higher Tier Only)
A rise in thyroxine inhibits its own release, so the level falls again.
A fall in thyroxine removes that inhibition, so more is released. The level is kept steady.
Which gland produces adrenaline? (Higher Tier Only)
The adrenal glands, above the kidneys.
What is the role of adrenaline? (Higher Tier Only)
It prepares the body for 'fight or flight' in a frightening or stressful situation.
It raises the heart rate and the blood glucose concentration.
How does raising heart rate help in a stressful situation? (Higher Tier Only)
More oxygen and glucose reach the muscles, so they can respire faster and release more energy.
________ controls the metabolic rate of the body. (Higher Tier Only)
Thyroxine controls the metabolic rate of the body.
True or False?
Adrenaline is released by negative feedback. (Higher Tier Only)
False.
Adrenaline is released in response to fear or stress. It is thyroxine that is controlled by negative feedback.
What is the main male reproductive hormone?
Testosterone.
Where is testosterone produced?
In the testes.
Give two effects of testosterone at puberty.
It stimulates sperm production.
It causes secondary sex characteristics such as body hair growth and a deeper voice.
What is the main female reproductive hormone?
Oestrogen.
Where is oestrogen produced?
In the ovaries.
Give two effects of oestrogen at puberty.
It starts the menstrual cycle.
It causes secondary sex characteristics such as breast development and widening of the hips.
What is the role of progesterone?
It maintains the lining of the uterus.
What does FSH stand for, and what does it do?
Follicle stimulating hormone.
It stimulates an egg to mature in the ovary.
What does LH stand for, and what does it do?
Luteinising hormone.
It stimulates ovulation — the release of the mature egg.
Define ovulation.
The release of a mature egg from the ovary.
Define secondary sex characteristics.
The physical changes, other than the reproductive organs themselves, that develop at puberty.
Which two hormones are produced by the ovaries?
Oestrogen and progesterone.
________ stimulates sperm production in males.
Testosterone stimulates sperm production in males.
The hormone that causes an egg to mature in the ovary is ________.
The hormone that causes an egg to mature in the ovary is FSH.
True or False?
Progesterone builds up the lining of the uterus.
False.
Oestrogen builds the lining up; progesterone maintains it.
True or False?
FSH and LH are both produced in the ovaries.
False.
Both are produced by the pituitary gland in the brain.
Which four hormones control the menstrual cycle? (Higher Tier Only)
FSH, LH, oestrogen and progesterone.
Which gland releases FSH and LH? (Higher Tier Only)
The pituitary gland, in the brain.
What does FSH do at the start of the cycle? (Higher Tier Only)
It stimulates a follicle to develop in the ovary, so an egg matures inside it.
It also stimulates the follicle to produce oestrogen.
What are the two effects of oestrogen? (Higher Tier Only)
It causes the uterus lining to grow and repair.
It inhibits FSH and, at a high enough level, stimulates the release of LH.
What does LH do? (Higher Tier Only)
It triggers ovulation, usually around day 14 of the cycle.
What triggers the release of LH? (Higher Tier Only)
Oestrogen rising to a high enough level.
What is the corpus luteum and what does it make? (Higher Tier Only)
The empty follicle left after ovulation.
It produces progesterone.
What is the role of progesterone? (Higher Tier Only)
It maintains the thickness of the uterus lining, ready to receive a fertilised egg.
What happens to the hormones if the egg is not fertilised? (Higher Tier Only)
The corpus luteum breaks down, so progesterone falls.
The uterus lining then breaks down, causing menstruation.
What happens to the hormones if the egg is fertilised? (Higher Tier Only)
The corpus luteum keeps producing progesterone, so the lining is maintained and the pregnancy continues.
Why does oestrogen inhibit FSH? (Higher Tier Only)
It stops further follicles maturing, so normally only one egg is released in a cycle.
On roughly which day does ovulation occur? (Higher Tier Only)
Around day 14 of a 28-day cycle.
A drop in ________ causes the uterus lining to break down at menstruation. (Higher Tier Only)
A drop in progesterone causes the uterus lining to break down at menstruation.
After ovulation the empty follicle becomes the ________. (Higher Tier Only)
After ovulation the empty follicle becomes the corpus luteum.
True or False?
FSH stimulates ovulation. (Higher Tier Only)
False.
LH stimulates ovulation. FSH matures the egg in the follicle.
True or False?
Progesterone stays high during pregnancy. (Higher Tier Only)
True.
It keeps the uterus lining intact so the pregnancy can continue.
Define contraception.
Methods used to prevent pregnancy.
Which two hormones are in the combined pill?
Oestrogen and progesterone.
How does the combined pill prevent pregnancy?
High oestrogen inhibits FSH, so no eggs mature.
Progesterone also stops eggs being released and thickens mucus so sperm cannot reach an egg.
What is the mini-pill?
A progesterone-only contraceptive pill, which has fewer side effects than the combined pill.
How do a contraceptive implant, injection or patch work?
They slowly release progesterone, which stops eggs maturing and being released, for months or years at a time.
Give one advantage of an implant over the pill.
It lasts for years, so there is no risk of forgetting to take it each day.
How do barrier methods prevent pregnancy?
They physically stop sperm from reaching the egg.
Name three barrier methods of contraception.
The condom, the femidom and the diaphragm.
What is the unique advantage of using a condom?
It is the only method that also protects against sexually transmitted infections.
What is natural family planning?
Avoiding intercourse during the fertile part of the menstrual cycle, around ovulation.
Why can natural family planning be unreliable?
Stress, illness or lifestyle changes can alter the menstrual cycle, so the fertile period is hard to predict.
Describe the two surgical methods of contraception.
Vasectomy — the sperm ducts are cut, so semen contains no sperm.
Female sterilisation — the oviducts are cut or tied, so eggs and sperm cannot meet.
Give one drawback of surgical contraception.
It is very difficult to reverse.
Which methods of contraception are the most reliable?
The implant, the IUD and sterilisation.
Only complete abstinence is 100% effective.
Give one drawback of hormonal methods of contraception.
They can cause side effects such as headaches, mood changes, weight gain or irregular periods.
How can human error reduce the effectiveness of contraception?
A method used incorrectly may fail — for example a condom that splits, or a pill taken at the wrong time.
The combined pill works mainly by inhibiting ________ so that no eggs mature.
The combined pill works mainly by inhibiting FSH so that no eggs mature.
True or False?
All methods of contraception protect against STIs.
False.
Only condoms act as a barrier to sexually transmitted infections.
True or False?
An IUD is a hormonal method of contraception.
False.
An IUD works by preventing implantation. Some types also release progesterone, but the device itself is not a hormonal method.
Which two hormones are given as fertility drugs? (Higher Tier Only)
FSH and LH.
Why is FSH given as a fertility treatment? (Higher Tier Only)
It stimulates eggs to mature in the ovaries.
Why is LH given as a fertility treatment? (Higher Tier Only)
It stimulates ovulation, so a mature egg is released.
Which fertility problems can hormone treatment help with? (Higher Tier Only)
Where too few eggs mature, or where no egg is released at ovulation.
What does IVF stand for? (Higher Tier Only)
In vitro fertilisation — 'in vitro' means 'in glass'.
Describe the main steps of IVF. (Higher Tier Only)
FSH and LH are given to stimulate egg production, and the eggs are collected from the ovary.
The eggs are fertilised with sperm in a dish, and the resulting embryos are placed into the uterus.
Why are several embryos implanted during IVF? (Higher Tier Only)
To increase the chance that at least one develops into a pregnancy.
Give one risk of hormone fertility treatment. (Higher Tier Only)
Several eggs may be released at once, raising the chance of a multiple birth such as twins or triplets.
Give two drawbacks of IVF. (Higher Tier Only)
It is expensive, so not every couple can afford it.
Implanting several embryos raises the risk of multiple births.
Why is a multiple birth considered a risk rather than a benefit? (Higher Tier Only)
Multiple pregnancies carry greater health risks for both the parent and the babies.
When might IVF be used instead of fertility drugs? (Higher Tier Only)
When someone still cannot conceive after taking fertility drugs, or where both partners have fertility problems.
In IVF, eggs are fertilised outside the body and the resulting ________ are placed in the uterus. (Higher Tier Only)
In IVF, eggs are fertilised outside the body and the resulting embryos are placed in the uterus.
________ is given to stimulate eggs to mature before they are collected for IVF. (Higher Tier Only)
FSH is given to stimulate eggs to mature before they are collected for IVF.
True or False?
In IVF, fertilisation happens inside the body. (Higher Tier Only)
False.
The egg and sperm are combined in a dish outside the body, which is what 'in vitro' means.
True or False?
Fertility treatment raises the chance of a multiple birth. (Higher Tier Only)
True.
Several eggs may be released, and in IVF several embryos are implanted.
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