Exam code: 7182
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Name the three types of drug therapy for addiction.
Aversives, agonists and antagonists.

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Define aversives in drug therapy.
Aversives are drugs that produce unpleasant consequences such as vomiting, e.g., disulfiram, which treats alcoholism by creating hypersensitivity to alcohol.
Define agonists.
Agonists act as drug substitutes by binding to neuron receptors and activating them.
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Name the three types of drug therapy for addiction.
Aversives, agonists and antagonists.
Define aversives in drug therapy.
Aversives are drugs that produce unpleasant consequences such as vomiting, e.g., disulfiram, which treats alcoholism by creating hypersensitivity to alcohol.
Define agonists.
Agonists act as drug substitutes by binding to neuron receptors and activating them.
Define antagonists.
Antagonists bind to receptor sites and block them so the drug cannot have its usual effects.
Nicotine addiction is treated using an substitution method, providing a safer alternative to smoking.
Nicotine addiction is treated using an agonist substitution method, providing a safer alternative to smoking.
In what forms is nicotine replacement therapy (NRT) delivered?
Mouth sprays, chewing gum, small pouches between the cheek and gums, and skin patches.
How does varenicline work?
It is a prescription partial agonist on nicotinic receptors, stimulating dopamine release while blocking nicotine from binding, for people who want to quit without NRT.
How does NRT work neurochemically?
Nicotine binds to nicotinic acetylcholine receptors in the mesolimbic pathway, stimulating dopamine release in the nucleus accumbens just as in smoking.
True or False?
NRT releases nicotine into the bloodstream faster than cigarettes.
False.
It is released more slowly and without the damaging chemicals found in tobacco.
How is NRT used to help someone give up nicotine completely?
The dose is reduced gradually over time, with withdrawal symptoms managed over two to three months.
True or False?
There is an officially approved drug for treating gambling addiction.
False.
No drug is officially approved, though opioid antagonists such as naltrexone are the most promising candidates under research.
Why are opioid antagonists being researched for gambling addiction?
Because of the similarities between gambling and substance addiction now recognised in DSM-5.
How does naltrexone reduce gambling cravings?
It enhances GABA release, reducing dopamine in the nucleus accumbens, so the brain's reward system is blocked when the person gambles.
What did Stead et al. (2012) conclude from reviewing 150 studies of NRT?
All forms of NRT beat placebo and no treatment, with users up to 70% more likely to be abstinent after six months; nasal spray was most effective.
What did Ward et al. (2018) find about naltrexone for gambling?
After six weeks all ten participants showed reduced cravings, and six gave up gambling completely.
Why is drug therapy for addiction considered convenient?
It only requires the individual to take a tablet daily rather than making wholesale changes to their thinking, as psychological therapies demand.
How does drug therapy help reduce the stigma of addiction?
It encourages people to view addiction as a medical problem rather than a moral weakness, making those affected more likely to seek help.
What are the side effects of NRT and naltrexone?
NRT causes sleep disturbances, gastro-intestinal problems and headaches; naltrexone's are more serious as the dose for gambling is much higher, so patients may discontinue.
What did Chung et al. (2012) suggest about drug treatments?
Naltrexone's effectiveness depends on a variation in a single gene, so treatments need to be tailored to genetic profiles.
Why are drug therapies for addiction biologically reductionist?
They treat addiction through chemical means alone, ignoring psychological, cognitive and social influences such as triggers and peer pressure.
What ethical concerns do drug therapies for addiction raise?
Side effects and varied responses across individuals raise concerns about informed consent and personalised care, despite reducing stigma.
Which learning principle is aversion therapy based on?
Classical conditioning and the principle of contiguity: two stimuli become associated if they frequently occur together.
Define counterconditioning.
Counterconditioning reduces addiction by associating the drug with an unpleasant state, breaking the pleasurable association and replacing it with a negative one.
How is aversion therapy used for alcohol addiction?
The client takes an aversive drug causing nausea, then drinks whisky minutes later so vomiting begins immediately, repeated until they no longer want to drink.
Whisky is used in aversion therapy because it has a particularly strong alcoholic and smell.
Whisky is used in aversion therapy because it has a particularly strong alcoholic taste and smell.
How is aversion therapy used for nicotine addiction?
The smoker inhales cigarette smoke rapidly and deeply enough to make them feel nauseous.
Describe aversion therapy for gambling addiction.
The gambler reads out cards with gambling-related and non-gambling phrases and receives a two-second electric shock for each gambling-related phrase.
True or False?
In aversion therapy for gambling, the therapist selects the shock intensity.
False.
The participant pre-selects the intensity, following instructions that it should be painful but not distressing.
Define covert sensitisation.
Covert sensitisation is aversion therapy carried out in vitro: the individual imagines the unpleasant stimulus rather than experiencing it.
Describe the procedure of covert sensitisation.
The client relaxes, imagines feeling nauseous and vomiting in detail, then imagines themselves smoking, drinking or gambling while holding the unpleasant images.
How can a client's phobia be used in covert sensitisation?
They may be asked to picture a rat or snake near or in their drink to strengthen the aversive imagery.
In covert sensitisation, the more the imagined situation, the greater the chance of conquering the addiction.
In covert sensitisation, the more negative the imagined situation, the greater the chance of conquering the addiction.
In covert sensitisation, what become the conditioned stimulus and response?
The addictive behaviour becomes the conditioned stimulus and the negative feelings become the conditioned response.
What did McConaghy et al. (1983) find?
At one-year follow-up, 90% of covert sensitisation clients had reduced gambling compared with 30% for electric shock aversion, with fewer and less intense cravings.
Why does covert sensitisation avoid the ethical problems of aversion therapy?
It uses no shock or induced vomiting, poses fewer medical risks, and allows clients to retain their dignity and self-esteem.
Why did aversion therapy fall in popularity?
Research questioned its efficacy, and inflicting extreme nausea, pain and loss of dignity came to be seen as ethically questionable.
What did Hajek & Stead (2001) conclude about aversion therapies for nicotine?
Reviewing 25 studies, effectiveness could not be judged because all but one had methodological problems, especially a failure to blind outcome evaluators.
True or False?
Behavioural interventions treat the underlying cause of addiction.
False.
They treat the behaviour, so other addictive behaviours may replace the one that has ceased (Griffiths, 1995).
Why are behavioural interventions for addiction reductionist?
They focus only on learned associations, ignoring biological, cognitive and social factors that contribute to addiction.
How do aversion therapy and covert sensitisation differ on free will?
Both assume addiction is determined by past learning, but covert sensitisation's reliance on mental imagery may better support the client's active role and free will.
What is the aim of CBT for addiction?
To change the faulty ways of thinking that lead people to use drugs or engage in behavioural addictions as maladaptive ways of coping.
Name the two indispensable elements of a CBT programme for addiction.
Cognitive restructuring and skills training.
Define functional analysis in CBT.
Functional analysis is the first stage of CBT, where client and therapist together identify the high-risk situations in which the client is likely to gamble or use a drug.
What should the client-therapist relationship in CBT be like?
Warm, collaborative and responsive but not cosy, as the therapist must challenge the client's distorted cognitions rather than accept them.
Define drug-refusal skills.
Drug-refusal skills are specific strategies equipping individuals to deal with the physical temptation and social pressures to take drugs.
What does cognitive restructuring tackle in CBT for addiction?
Biases operating below awareness, including faulty beliefs about probability, randomness, control, gains and losses, which the therapist confronts and challenges.
Relapse prevention training is a long-term technique focused on giving the individual over their addiction.
Relapse prevention training is a long-term technique focused on giving the individual control over their addiction.
Why is CBT described as a 'broad-spectrum' treatment?
It addresses wider aspects of the client's life related to addiction, using assertiveness training, anger management and social skills training.
How does assertiveness training help in CBT for addiction?
It helps clients confront interpersonal conflicts in a controlled, rational way instead of using avoidance, manipulation or aggression.
How does social skills training help in CBT for addiction?
Clients learn to refuse alcohol with minimum fuss, e.g., making appropriate eye contact and being firm in refusing a drink.
What did Cowlishaw et al. (2012) find?
CBT had medium to very large effects on gambling up to three months after treatment, but no significant difference from controls at nine to 12 months.
What did Petry et al. (2006) find?
Gamblers given Gamblers Anonymous plus eight CBT sessions gambled significantly less than GA-only controls up to 12 months later, and face-to-face CBT beat workbook delivery.
True or False?
CBT treats relapse as a failure of the treatment.
False.
Relapse is treated as an opportunity for further cognitive restructuring and an acceptable part of recovery if psychosocial functioning improves.
Why is the variety of CBT techniques a strength?
Techniques can be combined with drug therapies and delivered online or by phone, so treatment is tailored to individual needs.
What did Cuijpers et al. (2008) find about CBT?
Drop-out rates can be up to five times higher than for other therapies because CBT is demanding, and high-risk users complete fewer homework assignments.
Why is the flexibility of CBT also a limitation?
There is no standard treatment, so it is hard to establish which components work, and studies are not comparing a single consistent intervention.
How does CBT relate to the free will debate?
It assumes individuals have control over their thoughts and behaviours, supporting free will, unlike deterministic biological or learning models.
Why is CBT more holistic than biological therapies?
It addresses both cognitive and behavioural aspects of addiction, whereas biological therapies are reductionist, focusing on brain chemistry or genetics.
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