Exam code: 3430
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Define sense organ.
A group of receptor cells that responds to a specific stimulus and relays the information to the central nervous system.

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Define receptor.
A specialised cell that detects a change in the environment and stimulates an electrical impulse in response.
Name the six types of stimulus that receptor cells respond to.
Light
Sound
Touch
Temperature
Chemicals
Pressure and pain
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Define sense organ.
A group of receptor cells that responds to a specific stimulus and relays the information to the central nervous system.
Define receptor.
A specialised cell that detects a change in the environment and stimulates an electrical impulse in response.
Name the six types of stimulus that receptor cells respond to.
Light
Sound
Touch
Temperature
Chemicals
Pressure and pain
How is information carried from a sense organ to the central nervous system?
As electrical impulses travelling along neurones.
Which sense organ detects light, and which sense does it give?
The eye, which gives the sense of sight.
What is the ear sensitive to, and which two senses does it provide?
It is sensitive to sound and movement, giving the senses of hearing and balance.
What are the tongue and nose each sensitive to?
Tongue: chemicals in food and drink, giving taste
Nose: chemicals in the air, giving smell
What is the skin sensitive to?
Pressure, temperature changes and pain, giving the senses of touch and temperature.
Sense organs relay information to the central nervous system as electrical impulses along ________.
Sense organs relay information to the central nervous system as electrical impulses along neurones.
The ________ is the sense organ that detects chemicals in the air.
The nose is the sense organ that detects chemicals in the air.
True or False?
A single receptor cell can respond to any type of stimulus.
False.
Receptor cells are specific, each responding to one particular type of stimulus.
True or False?
The skin is a sense organ.
True.
It contains groups of receptor cells sensitive to pressure, temperature and pain.
Why is it useful for the body to have many different types of receptor?
So it can detect a wide range of changes in its internal and external environment and respond appropriately to each.
Define stimulus.
A change in the internal or external environment that is detected by receptor cells.
What three parts make up the human nervous system?
The brain
The spinal cord
All the nerves of the body
Define central nervous system.
The brain and the spinal cord.
What is the abbreviation for the central nervous system?
CNS.
Where do the nerves spread out to from the central nervous system?
To all other regions of the body, and importantly to all the sense organs.
The central nervous system consists of the brain and the ________.
The central nervous system consists of the brain and the spinal cord.
The brain, spinal cord and all the ________ of the body form the nervous system.
The brain, spinal cord and all the nerves of the body form the nervous system.
True or False?
The nerves in your arm are part of the central nervous system.
False.
Only the brain and spinal cord form the CNS. The other nerves connect the CNS to the rest of the body.
True or False?
The spinal cord is part of the central nervous system.
True.
The CNS is made up of the brain and the spinal cord.
What is the role of the central nervous system?
To receive information from the sense organs and coordinate a response, sending impulses out to the effectors.
Why does the nervous system need nerves as well as a CNS?
The nerves carry electrical impulses between the CNS and the rest of the body, including the sense organs and effectors.
Suggest why damage to the spinal cord can cause paralysis.
The spinal cord carries impulses between the brain and the body.
If it is damaged, impulses cannot reach the muscles below the injury, so they cannot be made to contract.
Which two organs of the nervous system are protected by bone?
The brain, protected by the skull
The spinal cord, protected by the vertebrae of the backbone
Define reflex action.
An involuntary response that does not involve the conscious part of the brain as coordinator.
State three properties of reflex actions.
Fast
Automatic
Some are protective
Describe the withdrawal reflex and its purpose.
Limb muscles contract to pull the limb away from a potentially damaging stimulus, such as high heat or a sharp object.
This protects the limb from harm.
How does blinking protect the eye?
Muscles in the eyelid contract to close the eye against a harmful stimulus such as an allergen or bright light, protecting the eye from damage.
Explain how changes in pupil size protect and help the eye.
The pupil becoming smaller protects the back of the eye from damage in bright light.
The pupil becoming larger lets more light in when conditions are dark.
When do you become aware that a reflex action has happened?
After the response has already been carried out. Reflexes do not involve the conscious brain.
A reflex action is an ________ response that does not involve the conscious part of the brain.
A reflex action is an involuntary response that does not involve the conscious part of the brain.
True or False?
You have to decide to blink when something comes towards your eye.
False.
Blinking is a reflex action. It is automatic and happens before you are consciously aware of it.
Define reflex arc. (Higher Tier Only)
The pathway taken by electrical impulses as they travel along neurones during a reflex response.
Name the four components of a reflex arc. (Higher Tier Only)
Stimulus
Receptor
Coordinator
Effector
Name the six structures you must be able to label on a reflex arc diagram. (Higher Tier Only)
Receptor
Sensory neurone
Relay neurone in the spinal cord
Motor neurone
Effector
Synapses
Describe the reflex arc for standing on a pin. (Higher Tier Only)
A receptor in the skin detects the stimulus.
A sensory neurone carries impulses to the coordinator in the spinal cord.
A relay neurone passes the impulse to a motor neurone across a synapse.
The motor neurone carries the impulse to a leg muscle, the effector, which contracts to pull the foot away.
What is the effector in a reflex arc? (Higher Tier Only)
A muscle or a gland that brings about the response.
In which direction does an impulse travel in a reflex arc? (Higher Tier Only)
Always from the stimulus and receptor, towards the spinal cord, and then out to the effector.
In a reflex arc, the ________ neurone carries the impulse from the receptor to the spinal cord. (Higher Tier Only)
In a reflex arc, the sensory neurone carries the impulse from the receptor to the spinal cord.
True or False?
The coordinator of a reflex arc is always in the spinal cord. (Higher Tier Only)
False.
For reflexes involving the eyes, such as blinking or the pupil reflex, the coordinator is in the brain, though never in its conscious part.
Define reaction time.
The time taken to respond to a stimulus. Reactions are usually very quick, typically less than a second.
Name three factors that can affect a person's reaction time.
Age
Stress
Use of drugs, such as caffeine
Describe the ruler drop method for measuring reaction time.
The volunteer rests their forearm on a table with their hand over the edge, thumb and fingers either side of a vertical ruler at the 0 cm mark.
The ruler is dropped without warning and the volunteer catches it as quickly as they can.
The number just above the thumb is recorded, and the test is repeated five times.
What does a lower catch distance on the ruler indicate?
A faster reaction time. The further down the ruler is caught, the quicker the response.
State the independent and dependent variables in this practical.
Independent variable: the person catching the ruler
Dependent variable: the reaction time, measured by the catch distance
Give three control variables for the ruler drop practical.
Using the dominant hand each time
Dropping the same ruler from the same height and angle
Keeping the ruler in the same orientation, with 0 cm facing down
Why is the test repeated five times for each volunteer?
To calculate a mean distance, which gives a more reliable measure of reaction time and allows anomalies to be spotted.
Give two sources of error in this practical.
Difficulty seeing exactly where the fingers caught the ruler
The ruler not being held in exactly the same position above the fingers each time
How could this practical be improved?
Use a computer to record reaction times, which removes human error, and record in milliseconds, which is more precise than seconds.
What is meant by translating data in this practical?
Converting the ruler drop distance in centimetres into a reaction time, using a conversion table.
The volunteer should hold the ruler at the ________ cm mark before it is dropped.
The volunteer should hold the ruler at the 0 cm mark before it is dropped.
Recording reaction times in ________ rather than seconds gives greater precision.
Recording reaction times in milliseconds rather than seconds gives greater precision.
True or False?
The ruler should be dropped without warning the volunteer.
True.
A warning would let the volunteer anticipate the drop, so the measurement would not reflect their true reaction time.
True or False?
Catching the ruler higher up means a faster reaction time.
False.
A higher catch point means the ruler fell further before being caught, so the reaction time was slower.
Define homeostasis.
The regulation of conditions inside an organism to keep them relatively constant and protected from harmful effects.
Name five internal conditions that are regulated by homeostasis.
Water content
Temperature
pH
Blood pressure
Blood glucose concentration
Why must internal conditions be kept within set limits?
To keep the organism healthy and maintain optimum conditions for it to function.
If the limits are exceeded, the organism may die.
Why is homeostasis essential for enzymes to work?
Enzymes only work within a narrow range of temperature and pH.
Homeostasis maintains those optimum conditions, so reactions in body cells can continue.
What would happen to enzymes if body temperature rose far above normal?
They would denature. Their active sites would lose shape, so the reactions of metabolism would stop.
________ is the regulation of internal conditions to keep them relatively constant.
Homeostasis is the regulation of internal conditions to keep them relatively constant.
Homeostasis maintains optimal conditions for ________ action and all cell functions.
Homeostasis maintains optimal conditions for enzyme action and all cell functions.
True or False?
Homeostasis keeps internal conditions exactly the same at all times.
False.
It keeps them relatively constant, fluctuating within set limits rather than staying at a fixed value.
True or False?
Blood glucose concentration is regulated by homeostasis.
True.
It is one of several internal conditions kept within set limits, alongside temperature, pH, water content and blood pressure.
Why does an organism need homeostasis when its external environment changes?
So its internal conditions stay within the narrow range its cells need, regardless of what is happening outside the body.
Explain the link between homeostasis and the survival of the whole organism.
Homeostasis maintains the conditions cells need for enzymes to work.
If cell reactions can continue, the cells stay alive, and so the organism as a whole can live.
Give two internal conditions that must be regulated for enzymes to function.
Temperature
pH
Define hormone.
A chemical substance produced by a gland and carried by the blood, which alters the activity of one or more target organs.
Where are hormones produced?
In glands.
How are hormones transported around the body?
In the blood.
Define target organ.
The organ whose activity is altered by a particular hormone.
Define endocrine system.
The collective name for all the glands that produce hormones in an animal.
Why are hormones described as chemical messengers?
They transmit information from one part of the organism to another and bring about a change in the target organ.
Hormones are carried around the body in the ________.
Hormones are carried around the body in the blood.
The glands that produce hormones are known collectively as the ________ system.
The glands that produce hormones are known collectively as the endocrine system.
True or False?
Hormones travel along neurones to reach their target organ.
False.
Hormones are carried in the blood. Electrical impulses travel along neurones.
True or False?
A hormone only affects specific target organs.
True.
Although a hormone travels all round the body in the blood, it only alters the activity of its target organs.
Give one example of a hormone and the organ that produces it.
Insulin, produced by the pancreas, which lowers blood glucose concentration.
Suggest why hormonal responses are generally slower than nervous responses.
Hormones must be carried in the blood to reach their target organ, which takes longer than an electrical impulse travelling along a neurone.
Which organ monitors and controls blood glucose concentration?
The pancreas.
Describe what happens when blood glucose concentration gets too high.
Cells in the pancreas detect the rise.
The pancreas secretes the hormone insulin into the blood.
Insulin causes the liver and muscles to take up glucose and store it as glycogen.
Blood glucose falls back to normal and insulin secretion stops.
Define insulin.
A protein hormone released by the pancreas that lowers blood glucose by causing the liver to convert glucose into glycogen.
Define glycogen.
The insoluble storage form of glucose, stored in the liver and muscles.
Which organ stores glucose as glycogen?
The liver, and also the muscles.
Why is a blood glucose level that is too high dangerous?
Cells of the body can lose water by osmosis, because the blood becomes too concentrated.
Why is a blood glucose level that is too low dangerous?
The brain receives insufficient glucose for respiration, which can lead to a coma or even death.
Why is glycogen a good storage molecule?
It is insoluble, so it can be stored without affecting the water balance of cells by osmosis.
The pancreas releases the hormone ________ when blood glucose levels rise.
The pancreas releases the hormone insulin when blood glucose levels rise.
Insulin causes the liver to convert glucose into insoluble ________ for storage.
Insulin causes the liver to convert glucose into insoluble glycogen for storage.
True or False?
Insulin is a protein.
True.
Insulin is a protein hormone secreted into the blood by the pancreas.
True or False?
The pancreas keeps secreting insulin at the same rate all the time.
False.
The pancreas stops secreting insulin once blood glucose has returned to normal levels.
Why is the control of blood glucose an example of homeostasis?
Blood glucose concentration must be kept within a narrow range, so the body constantly regulates it to keep internal conditions relatively constant.
What happens to blood glucose shortly after a meal high in carbohydrate?
It rises sharply as the carbohydrate is digested to glucose and absorbed.
The pancreas then releases insulin to bring it back down.
Define diabetes.
A common disease in which a person has a high blood glucose level.
What causes type 1 diabetes?
The pancreas fails to produce sufficient insulin.
Scientists think this results from the person's immune system destroying the insulin-producing cells of the pancreas.
What causes type 2 diabetes?
The body cells no longer respond properly to insulin.
The person still produces insulin, but their cells are resistant to it.
Give the main treatments for type 1 diabetes.
Insulin injections, several times a day
A controlled diet, limiting simple carbohydrates that raise blood sugar quickly
In rare cases, a pancreas transplant
Give the main treatments for type 2 diabetes.
A carbohydrate-controlled diet
A regular exercise regime
Which lifestyle factor is the biggest risk factor for type 2 diabetes?
Obesity, often linked to a diet high in carbohydrates and a lack of exercise.
How can diabetes be detected from a urine sample?
By testing for the presence of glucose in the urine, using Benedict's solution.
Describe how to test a urine sample for glucose.
Add equal volumes of the urine sample and Benedict's solution to a test tube.
Gently heat the solution for five minutes.
If glucose is present, the solution turns from blue to orange.
In type 1 diabetes the pancreas fails to produce sufficient ________.
In type 1 diabetes the pancreas fails to produce sufficient insulin.
________ solution is used to test a urine sample for the presence of glucose.
Benedict's solution is used to test a urine sample for the presence of glucose.
True or False?
People with type 2 diabetes produce no insulin at all.
False.
They still produce insulin, but their body cells have become resistant to it.
True or False?
Type 1 diabetes is usually treated with insulin injections.
True.
Because the pancreas cannot make enough insulin, it must be injected, normally several times a day.
Why does glucose appear in the urine of someone with untreated diabetes?
Blood glucose is so high that the excess is excreted in the urine rather than being stored in the liver as glycogen.
Why should someone with type 1 diabetes limit simple carbohydrates?
Simple carbohydrates are converted quickly into glucose, causing blood sugar to rise rapidly, which is harder to control.
Name the six structures you must be able to label on a diagram of the skin.
Hair
Erector muscle
Sweat gland
Sweat duct
Sweat pore
Blood vessels
At approximately what temperature does the human body work best, and why?
About 37 °C.
This is the temperature at which enzymes work best. Above it they begin to denature.
Define vasodilation.
The widening of blood vessels near the skin surface, which increases blood flow to the capillaries so more heat is lost by radiation.
Define vasoconstriction.
The narrowing of blood vessels leading to the skin capillaries, which reduces blood flow near the surface so less heat is lost by radiation.
Explain how sweating cools the body.
Sweat is secreted onto the skin by sweat glands.
It evaporates, which uses heat energy from the body to turn liquid water into water vapour, cooling the skin.
Explain how the erection of hairs helps when the body is cold.
The erector muscles contract, making the hairs stand on end.
This traps a layer of air over the skin, which insulates the body and reduces heat loss by radiation.
Explain how shivering warms the body.
It is a reflex action in which muscles contract rapidly and regularly.
The respiration needed to power this releases enough heat to warm the blood and raise core body temperature.
State the three responses of the skin when the body is too hot.
Vasodilation of blood vessels near the surface
Sweating
Hairs lie flat
State the three responses when the body is too cold.
Vasoconstriction of blood vessels near the surface
Erection of hairs to trap an insulating layer of air
Shivering to generate heat
When we are hot, blood vessels near the skin surface widen. This is called ________.
When we are hot, blood vessels near the skin surface widen. This is called vasodilation.
Sweat cools the skin by ________, which uses heat energy from the body.
Sweat cools the skin by evaporation, which uses heat energy from the body.
True or False?
Blood vessels move closer to the skin surface when we are hot.
False.
The blood vessels do not move. They widen (vasodilate), so more blood flows through the capillaries near the surface.
True or False?
Shivering is a reflex action.
True.
It happens automatically in response to a fall in core body temperature.
Why is the skin described as the body's largest sense organ?
It contains many receptors across the whole body surface that detect touch, pressure, pain, heat and cold.
Why is controlling body temperature so important?
Enzymes work best at about 37 °C. If the body gets too hot they denature and can no longer catalyse reactions such as respiration.
Define negative feedback. (Higher Tier Only)
A control mechanism that returns conditions to a set point when they change from the ideal.
How does a negative feedback mechanism work? (Higher Tier Only)
If a level rises, control systems switch on to reduce it
If a level falls, control systems switch on to raise it
Name two body conditions controlled by negative feedback. (Higher Tier Only)
Core body temperature
Blood glucose concentration
Which two hormones control blood glucose by negative feedback? (Higher Tier Only)
Insulin, which lowers blood glucose
Glucagon, which raises blood glucose
Describe what happens when blood glucose falls too low. (Higher Tier Only)
Cells in the pancreas detect the fall.
The pancreas produces glucagon.
Glucagon causes glycogen in the liver to be converted into glucose and released into the blood.
Blood glucose rises back to normal and glucagon secretion stops.
Which two organs work together to control blood glucose? (Higher Tier Only)
The pancreas, which makes the hormones, and the liver, which stores and releases glycogen.
Which two body systems bring about negative feedback responses? (Higher Tier Only)
The hormonal system and the nervous system.
Give a memory aid for the roles of insulin and glucagon. (Higher Tier Only)
INsulin takes glucose IN to the liver
GlucaGON is needed when glucose is GONe
________ causes glycogen in the liver to be converted back into glucose. (Higher Tier Only)
Glucagon causes glycogen in the liver to be converted back into glucose.
Negative feedback returns conditions to the ideal value, known as the ________ point. (Higher Tier Only)
Negative feedback returns conditions to the ideal value, known as the set point.
True or False?
Negative feedback holds a condition at exactly one fixed value. (Higher Tier Only)
False.
It is a continuous cycle of raising and lowering, keeping the condition within a narrow range around the set point.
True or False?
Insulin and glucagon have opposite effects on blood glucose. (Higher Tier Only)
True.
Insulin lowers blood glucose by storing it as glycogen, while glucagon raises it by converting glycogen back to glucose.
Explain how temperature control is an example of negative feedback. (Higher Tier Only)
If core temperature rises above the set point, vasodilation and sweating cool the body.
If it falls, vasoconstriction, hair erection and shivering warm it.
Either way, the response returns temperature to the set point.
Define lifestyle choice.
A conscious decision an individual makes that may increase or decrease their risk of disease.
Give four examples of lifestyle choices that affect health.
Consumption of alcohol
Smoking cigarettes
Diet
Amount of exercise
How does alcohol affect reaction time, and why?
Reaction time is generally lowered, because alcohol affects the nervous system.
Give three short-term effects of drinking alcohol.
Any three of:
Slurred speech
Loss of balance
Loss of inhibitions and aggressive behaviour
Blurred vision
Give three long-term effects of alcohol abuse.
Liver disease, such as cirrhosis
Cancers, such as mouth cancer
Circulatory and heart disease, as alcohol raises blood pressure
Why does long-term alcohol abuse damage the liver?
The liver is the main site of drug metabolism.
Breaking down alcohol produces toxic waste products that damage liver cells, leading to conditions such as cirrhosis.
How can alcohol cause cancer?
Toxic products from its breakdown can damage DNA, causing cancerous cell mutations.
What are withdrawal symptoms, and give two examples for alcohol.
Symptoms experienced when an addicted person stops taking a substance.
For alcohol these include headaches, depression and body tremors.
How is type 2 diabetes linked to lifestyle?
A poor diet and a lack of exercise increase the chance of developing it.
Obesity is a major risk factor.
The ________ is the primary site of drug metabolism in the body.
The liver is the primary site of drug metabolism in the body.
________ is a major risk factor for developing type 2 diabetes.
Obesity is a major risk factor for developing type 2 diabetes.
True or False?
Only illegal drugs can be harmful to the body.
False.
All drugs, legal medicinal ones included, can be harmful if misused or overused.
True or False?
Alcohol is a poisonous substance.
True.
Alcohol is a poison that changes various chemical processes in the body.
Give two examples of drug misuse.
Drugs taken to boost sporting performance
Illegal recreational drugs such as ecstasy, cocaine and heroin
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